Akt/CREB/Cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate (TRAMP) model mediated by Nexrutine® a Phellodendron amurense bark extract

摘要

Purpose Development of prostate cancer (PCA) prevention strategies is an important priority to overcome high incidence, morbidity & mortality. Recently, we demonstrated that Nexrutine®, an herbal extract inhibits prostate cancer cell proliferation through modulation of Akt and CREB-mediated signaling pathways. However, it is unknown if Nexrutine® can be developed as a dietary supplement for the prevention of PCA. In this study, we used the transgenic adenocarcinoma of mouse prostate (TRAMP) model to examine the ability of Nexrutine® to protect TRAMP mice from developing prostate cancer.