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Gene Targeting Demonstrates That α4 Nicotinic Acetylcholine Receptor Subunits Contribute to Expression of Diverse 3HEpibatidine Binding Sites and Components of Biphasic 86Rb+ Efflux With High and Low Sensitivity to Stimulation by Acetylcholine

机译：基因靶向证明α4烟碱乙酰胆碱受体亚基有助于表达不同的3H Epibatidine结合位点和双相86Rb +外排组分对乙酰胆碱刺激具有高和低敏感性。

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期刊名称 other
作者
Michael J. Marks; Natalie M. Meinerz; John Drago; Allan C. Collins;
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年(卷),期 -1(53),3
年度 -1
页码 390–405
总页数 29
原文格式 PDF
正文语种
中图分类
关键词
Null mutant mice Nicotinic acetylcholine receptor Epibatidine sup86/supRbsup+/sup efflux Cytisine Dihydro-β-erythroidine;

机译：无效的突变小鼠;烟碱型乙酰胆碱受体;依巴替丁;sup 86 / sup Rb sup + / sup外排;胱氨酸;二氢-β-类胡萝卜素;

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1. Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse ((3)H)epibatidine binding sites and components of biphasic (86)Rb(+) efflux with high and low sensitivity to stimulation by acetylch [J] . Marks MJ, Meinerz NM, Drago J, Neuropharmacology . 2007,第3期

机译：基因靶向表明，α4烟碱乙酰胆碱受体亚基有助于表达不同的（（3）H）epibatidine结合位点和双相（86）Rb（+）外排的成分，对乙酰胆碱刺激具有高敏感性和低敏感性
2. Partial deletion of the nicotinic cholinergic receptor alpha 4 or beta 2 subunit genes changes the acetylcholine sensitivity of receptor-mediated 86Rb+ efflux in cortex and thalamus and alters relative expression of alpha 4 and beta 2 subunits. [J] . Gotti C, Moretti M, Meinerz NM, Molecular pharmacology. . 2008,第6期

机译：烟碱胆碱能受体α4或β2亚基基因的部分缺失改变了皮质和丘脑中受体介导的86Rb +外排的乙酰胆碱敏感性，并改变了α4和β2亚基的相对表达。
3. 86Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization. [J] . Marks MJ, Meinerz NM, Brown RW, Biochemical Pharmacology . 2010,第8期

机译：由α4beta2*烟碱型乙酰胆碱受体介导的86Rb +外排对乙酰胆碱刺激具有高敏感性和低敏感性，表现出相似的激动剂诱导的脱敏作用。
4. Nicotinic acetylcholine receptors as target sites for neonicotinoid insecticides [C] . N S Millar International Plant Protection Congress . 2007

机译：烟碱乙酰胆碱受体作为Neonicotinoid杀虫剂的靶位点
5. Heterologous expression of α6*-nicotinic acetylcholine receptors and the natural distribution of α6 subunits [D] . Buhlman, Lori Marie 2007

机译：α6*-烟碱型乙酰胆碱受体的异源表达和α6亚基的自然分布
6. 86Rb+ Efflux Mediated by α4β2*-Nicotinic Acetylcholine Receptors with High and Low Sensitivity to Stimulation by Acetylcholine Display Similar Agonist-Induced Desensitization [O] . Michael J. Marks, Natalie M. Meinerz, Robert W. B. Brown, -1

机译：由乙酰胆碱显示相似的激动剂诱导的脱敏由α4β2* - 致致乙酰胆碱受体介导的α4β2* - 肌约乙酰胆碱受体介导的α4β2* - 致胰岛素受体。
7. 86Rb+ efflux mediated by α4β2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization [O] . Michael J. Marks, Natalie M. Meinerz, Robert W.B. Brown, 2010

机译：由乙酰胆碱显示相似的激动剂诱导的脱敏，由α4β2* - 高致乙酰胆碱受体介导的α4β2* - 硝基乙酰胆碱受体介导的α4β2* - 肌约乙酰胆碱受体介导。
8. Sensitivity Increase in Nicotinic Acetylcholine Receptor Binding in Fiber OpticWave Guide [R] . Menking, D. E., Thompson, R. G., Heitz, J. M., 1995

机译：光纤波导指南中烟碱乙酰胆碱受体结合的灵敏度增加

Gene Targeting Demonstrates That α4 Nicotinic Acetylcholine Receptor Subunits Contribute to Expression of Diverse 3HEpibatidine Binding Sites and Components of Biphasic 86Rb+ Efflux With High and Low Sensitivity to Stimulation by Acetylcholine

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