Distinct Regulation of IL-17 in Human Helper T Lymphocytes

摘要

ObjectiveIL-17 producing helper T cells have been proposed to represent a separate lineage of CD4⁺ cells, designated Th17 cells, which are regulated by the transcription factor RORγt. However, despite advances in understanding murine Th17 differentiation, a systematic assessment of factors that promote the differentiation of naïve human T cells to Th17 cells has not been reported. This present study was undertaken to assess the effects of cytokines known to promote murine Th17 cells on naïve human CD4⁺ T cells.