Variation in Age at ESRD in Autosomal Dominant Polycystic Kidney Disease

摘要

BackgroundHeterogeneity manifest as more severe disease in successive generations has been attributed to genetic anticipation in patients with autosomal dominant polycystic kidney disease (ADPKD). We evaluated variation in age at end-stage renal disease (ESRD) in ADPKD families for evidence of anticipation.