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Hypoxia-inducible factor-2α: effect on radiation sensitivity and differential regulation by an mTOR inhibitor

机译：缺氧诱导因子-2α：mTOR抑制剂对放射敏感性和差异调节的影响

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OBJECTIVETo determine the role of hypoxia-inducible factor-2α (HIF2α) on the sensitivity of renal cell carcinoma (RCC) cell lines to ionizing radiation and to determine if the mTOR antagonist, rapamycin, could decrease HIF2α protein levels.

机译：目的确定缺氧诱导因子2α（HIF2α）在肾细胞癌（RCC）细胞对电离辐射敏感性中的作用，并确定mTOR拮抗剂雷帕霉素是否可以降低HIF2α蛋白水平。

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期刊名称 other
作者
Rupal S. Bhatt; Daniel M. Landis; Michael Zimmer; Joelle Torregrossa; Shaoyong Chen; Vikas P. Sukhatme; Othon Iliopoulos; Steve Balk; Glenn J. Bubley;
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作者单位

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年(卷),期 -1(102),3
年度 -1
页码 358–363
总页数 15
原文格式 PDF
正文语种
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关键词
renal cancer radiation hypoxia hypoxia-inducible factor;

机译：肾癌;放射线;缺氧;缺氧诱导因子;

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专利

1. Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor. [J] . Bhatt RS, Landis DM, Zimmer M, BJU international . 2008,第3期

机译：缺氧诱导因子2α：通过mTOR抑制剂对放射敏感性和差异调节的影响。
2. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL, Department of Pathology and Laboratory Medicine, David Geffen School of Med [J] . Slaton JW Urologic oncology . 2006,第5期

机译：缺氧诱导因子决定了对肾癌中mTOR抑制剂的敏感性Thomas GV，Tran C，Mellinghoff IK，Welsbie DS，Chan E，Fueger B，Czernin J，Sawyers CL，大卫·格芬医学院的病理学和检验医学系
3. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. [J] . Thomas GV, Tran C, Mellinghoff IK, Nature medicine . 2006,第1期

机译：缺氧诱导因子决定了对肾癌中mTOR抑制剂的敏感性。
4. Label-Free Quantitative Proteomics of Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2α Expression [C] . Tatjana Talamantes, Lokesh Dalasanur Nagaprashantha, Sharad S. Singhal, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：肾细胞癌的无标记定量蛋白质组学，具有差异缺氧诱导因子-2α表达
5. Clinical Pharmacokinetics of the Novel Combination of BEZ235, PI3K/mTOR Inhibitor, and Everolimus, mTOR Inhibitor: Phase I Clinical Studies and Non-Clinical Mechanistic Assessment [D] . Moorthy, Ganesh P. 2015

机译：BEZ235，PI3K / mTOR抑制剂和依维莫司，mTOR抑制剂的新型组合的临床药代动力学：I期临床研究和非临床机制评估
6. Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2α Expression [O] . Lokesh Dalasanur Nagaprashantha, Tatjana Talamantes, Jyotsana Singhal, -1

机译：缺氧诱导因子-2α差异表达在肾细胞癌中信号网络调控的蛋白质组学分析
7. Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells [O] . Victoria Wang, David A. Davis, Muzammel Haque, 2005

机译：HEK293T细胞中缺氧诱导因子-1α和缺氧诱导因子-2α的差异基因上调

Hypoxia-inducible factor-2α: effect on radiation sensitivity and differential regulation by an mTOR inhibitor

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