Method for producing the copolymer - mTOR inhibitor system, intended for coating the polymer vascular stents and the application of the copolymer - mTOR inhibitor system for production of the coating with controlled kinetics of releasing of the mTOR inhibitor on the polymer vascular stents

摘要

the object of the application is a manufacturing system copolymer - mtor inhibitor, intended for coating polymeric vascular stents, which is thatthat produces a copolymer of trimethylene carbonate and laktydu using as reaction initiator kopolimeryzacji compounds of zirconium (iv)and then the obtained copolymer poly (trimethylene carbonate laktydo - ko) is dissolved in an organic solvent with high volatility, preferably methylene chloride, to obtain a solution with a concentration of 0.5 - 5.0% by weight, preferably 1 to 2% by weight and added to his previously prepared solution of mtor pathway.favourably sirolimus or ewerolimusu in organic solvent of high volatility, preferably methylene chloride at a concentration of 1 to 13% by weight - volume and whole mixeduntil a homogeneous solution containing inhibitor of mtor pathway for working, which when added to polimerowy vascular stent, a coating thickness of 0.8 - 5,0 mm favourably about,after removal of solvent containing 5 - 40% by weight zdyspergowanego in the mtor inhibitor compared to poly (trimethylene carbonate laktydo - ko), and preferably 20 to 30% by weight.the coating is formed by dipping the stent in the working solution, with the speed of dipping 40 - 3000 mm / min, by 0.1 - 30 s, with the quantity of cycles 1 - 50, and the duration of the dive is from 0.2 - 50 s / cycle. formed coating is dried, utwardzana and at the final stage of sterilised, advantageously using radiation jonizacyjnego.the declaration also includes use of the copolymer inhibitor the mtor to manufacture coating controlled release kinetics of mtor inhibitor.