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NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of FLT as a Marker of Proliferation in Patients with Recurrent Gliomas: Safety Studies

机译：NCI赞助的用于评估FLT作为复发性胶质瘤患者增殖指标的安全性和初步疗效的试验：安全性研究

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摘要

Purpose3’-[F-18]Fluoro-3’-deoxythymidine (FLT) is an analog of thymidine that is being developed for imaging cellular proliferation. The goal of this study was to prove that the dose of FLT used for positron emission tomography imaging produces no significant toxicity.

机译：目的3'-[F-18]氟-3'-脱氧胸苷（FLT）是胸腺嘧啶的类似物，其正被开发用于成像细胞增殖。这项研究的目的是证明用于正电子发射断层扫描成像的FLT剂量不会产生明显的毒性。

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期刊名称 other
作者
Alexander M. Spence; Mark Muzi; Jeanne M. Link; John M. Hoffman; Janet F. Eary; Kenneth A. Krohn;
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作者单位

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年(卷),期 -1(10),5
年度 -1
页码 271–280
总页数 23
原文格式 PDF
正文语种
中图分类
关键词
3’-F-18fluoro-3’-deoxythymidine FLT Fluorothymidine Positron emission tomography (PET) Glioma Glioblastoma Safety Toxicity Proliferation;

机译：3’-F-18氟-3’-脱氧胸苷;FLT;氟胸苷;正电子发射断层扫描（PET）;神经胶质瘤;成胶质细胞瘤;安全性;毒性;增殖;

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专利

1. NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of 3′-Deoxy-3′-[18F]fluorothymidine (FLT) as a Marker of Proliferation in Patients with Recurrent Gliomas: Preliminary Efficacy Studies [J] . Alexander M. Spence, Mark Muzi, Jeanne M. Link, Molecular Imaging and Biology . 2009,第5期

机译：NCI赞助的评估3'-脱氧-3'-[18 F]氟胸苷（FLT）作为复发性胶质瘤患者增殖指标的安全性和初步疗效的初步疗效研究
2. NCI-sponsored trial for the evaluation of safety and preliminary efficacy of 3'-deoxy-3'-(18F)fluorothymidine (FLT) as a marker of proliferation in patients with recurrent gliomas: preliminary efficacy studies. [J] . Spence AM, Muzi M, Link JM Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2009,第5期

机译：由NCI发起的评估3'-脱氧-3'-（18F）氟胸苷（FLT）作为复发性神经胶质瘤患者增殖指标的安全性和初步疗效的试验：初步疗效研究。
3. NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of FLT as a Marker of Proliferation in Patients with Recurrent Gliomas: Safety Studies [J] . Alexander M. Spence, Mark Muzi, Jeanne M. Link, Molecular Imaging and Biology . 2008,第5期

机译：NCI赞助的用于评估FLT作为复发性胶质瘤患者增殖指标的安全性和初步疗效的试验：安全性研究
4. Inununohistochemical and Molecular Markers of Proliferation and Apoptosis in Stereotactic Bioptates of Brain Gliomas Prognosis of the Course of the Disease and the Treatment Efficacy [C] . G. Bierzynska-Macyszyn, U. Mazurek, P. Wlaszczuk, World Society for Stereotactic and Functional Neurosurgery . 2005

机译：疾病过程脑胶质瘤脑胶质瘤脑胶质术后凋亡和细胞凋亡的肝细胞化学和分子标记及治疗疗效
5. An evaluation of the relationships between safety management system initiatives, transformational safety leadership, self-efficacy, safety behavior, and safety-related events mediated by safety motivation in collegiate aviation. [D] . Adjekum, Daniel Kwasi. 2016

机译：对大学航空安全管理体系举措，变革型安全领导，自我效能，安全行为以及由安全动机介导的安全相关事件之间的关系进行评估。
6. NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of 3′-Deoxy-3′-18F fluorothymidine (FLT) as a Marker of Proliferation in Patients with Recurrent Gliomas: Preliminary Efficacy Studies [O] . Alexander M. Spence, Mark Muzi, Jeanne M. Link, -1

机译：NCI赞助试验用于评估3-DEOXY-3 - 18F氟脲酰胺（FLT）作为复发性胶质瘤患者的增殖标志物：初步疗效研究
7. Phase II Study to Evaluate the Efficacy and Safety of Rilotumumab and Bevacizumab in Subjects with Recurrent Malignant Glioma [O] . Mary Lou Affronti, Jennifer Gamboa Jackman, Frances McSherry, 2018

机译：II期研究，评价Rilotumumab和Bevacizumab在具有复发性恶性胶质瘤的受试者中的疗效和安全性

NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of FLT as a Marker of Proliferation in Patients with Recurrent Gliomas: Safety Studies

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