Synthesis Photochromic Properties and Light-Controlled Metal Complexation of a Naphthopyran Derivative

摘要

A light-controlled reversible binding switch based on photochromic 3H-naphtho[2,1-b]pyran is under development for studying cellular oscillatory calcium signals. The binding affinities of the closed and open forms of substituted naphthopyran 1 for Ca²⁺, Mg²⁺, and Sr²⁺ in buffer were determined. The photochemically ring-opened form of the receptor exhibited increased affinity compared to the thermally stable closed form of the receptor. The binding affinity difference for Ca²⁺ was ∼77-fold at pH 7.6.