The anti-inflammatory limb of the immune response in preterm labor intra-amniotic infection/inflammation and spontaneous parturition at term: A role for Interleukin-10.

摘要

OBJECTIVE:The anti-inflammatory limb of immune response is crucial for dampening inflammation. Spontaneous parturition at term and preterm labor are mediated by inflammation in the cervix, membranes and myometrium. This study focuses on the changes in the amniotic fluid concentrations of the anti-inflammatory cytokine IL-10. The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm) and intra-amniotic infection/inflammation (IAI).