DYNAMIC CHANGES IN MATRIX METALLOPROTIENASE ACTIVITY WITHIN THE HUMAN MYOCARDIAL INTERSTITIUM DURING MYOCARDIAL ARREST AND REPERFUSION

摘要

BackgroundPast studies have clearly established that matrix metalloproteinases (MMPs) contribute to adverse myocardial remodeling with ischemia and reperfusion. However, these studies measured MMP levels in extracted samples, and therefore whether and to what degree actual changes in interstitial MMP activity occur within the human myocardium in the context of ischemia/reperfusion remained unknown.