Genome-wide Strategies for Discovering Genetic Influences on Cognition and Cognitive Disorders: Methodological Considerations

摘要

IntroductionGenes play a well-documented role in determining normal cognitive function. This paper focuses on reviewing strategies for the identification of common genetic variation in genes that modulate normal and abnormal cognition with a genome-wide association scan (GWAS). GWASs make it possible to survey the entire genome to discover important but unanticipated genetic influences.