Background and PurposeIt is not possible to determine if babies diagnosed with Krabbe disease through statewide newborn screening programs will develop disease as infants, juveniles or adults. The only available treatment for this fatal neurodegenerative condition is unrelated umbilical cord transplantation but this treatment is only effective before clinical symptoms appear. Therefore, a marker of disease progression is needed. The purpose of this study was to evaluate the use of Diffusion Tensor Imaging (DTI) with fiber tracking in identifying early changes in major motor tracts of asymptomatic neonates with infantile Krabbe disease.
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