Enantio- and Diastereoselective Intermolecular Stetter Reaction of Glyoxamide and Alkylidene Ketoamides

摘要

A triazolinylidine carbene catalyzed intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides has been developed. 1,4-dicarbonyl products are afforded in good to excellent yields, enantioselectivities and diastereoselectivities. Further derivatization of the products affords useful intermediates for organic synthesis.