Downregulation of ZIP4 by RNA Interference Inhibits Pancreatic Cancer Growth and Increases the Survival of Nude Mice with Pancreatic Cancer Xenografts

摘要

PurposeZinc levels have been correlated with cancer risk, though the role of zinc and zinc transporters in cancer progression is largely unknown. We have recently found that a zinc transporter, ZIP4, is overexpressed in pancreatic cancer. In this study, we have further deciphered the role that ZIP4 plays in a pancreatic cancer mouse model by silencing ZIP4.