An Adaptive Nonlinear Basal-Bolus Calculator for Patients With Type 1 Diabetes

摘要

Background:Bolus calculators help patients with type 1 diabetes to mitigate the effect of meals on their blood glucose by administering a large amount of insulin at mealtime. Intraindividual changes in patients physiology and nonlinearity in insulin-glucose dynamics pose a challenge to the accuracy of such calculators.