Abuse liability of intravenous buprenorphinealoxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers

摘要

BACKGROUNDSublingual buprenorphine is an effective maintenance treatment for opioid dependence, yet intravenous buprenorphine misuse occurs. A buprenorphinealoxone formulation was developed to mitigate this misuse risk. This randomized, double-blind, crossover study was conducted to assess the intravenous abuse potential of buprenorphinealoxone compared with buprenorphine in buprenorphine-maintained injection drug users (IDUs).