Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2

摘要

BackgroundGenome-wide association studies (GWAS) have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer scan, a single-nucleotide polymorphism (SNP) rs10486567 located within intron 2 of JAZF1 gene on chromosome 7p15.2 showed a promising association with PrCa overall (p = 2.14×10⁻⁶) with a suggestion of stronger association with aggressive disease (p = 1.2×10⁻⁷).