It is generally accepted that unreliable in vivo performance of implantable glucose sensors originates, in large part, from tissue reactions to the implanted sensor, including foreign body reactions (i.e., inflammation, fibrosis, and vessel regression). Development of glucose sensor coatings with increased biocompatibility would contribute to the development of a reliable long-term glucose sensor. In this issue of Journal of Diabetes Science and Technology, Van den Bosch and coauthors report on their initial in vitro results on a candidate biocompatibility coating for sensors (silica nanoparticle- polyethylene-glycol-based coating). Although the initial standard testing is encouraging, it is important that sensor-specific testing protocol be utilized to more accurately predict sensor performance in vivo. The development and application of sensor-specific testing standards will likely speed the development of biocompatible coatings that will increase sensor accuracy and lifespan in the future.
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机译：通常认为，植入式葡萄糖传感器的不可靠的体内性能在很大程度上源于对植入式传感器的组织反应，包括异物反应（即炎症，纤维化和血管退化）。具有提高的生物相容性的葡萄糖传感器涂层的开发将有助于可靠的长期葡萄糖传感器的开发。在本期《糖尿病科学与技术杂志》上，Van den Bosch和合著者报告了他们在候选传感器生物相容性涂层（二氧化硅纳米颗粒-聚乙二醇基涂层）上的初步体外结果。尽管最初的标准测试令人鼓舞，但重要的是要利用传感器特定的测试协议来更准确地预测体内传感器的性能。传感器专用测试标准的开发和应用可能会加速生物相容性涂层的开发，这将在未来提高传感器的准确性和使用寿命。
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