Simulation Environment to Evaluate Closed-Loop Insulin Delivery Systems in Type 1 Diabetes

摘要

BackgroundClosed-loop insulin delivery systems linking subcutaneous insulin infusion to real-time continuous glucose monitoring need to be evaluated in humans, but progress can be accelerated with the use of in silico testing. We present a simulation environment designed to support the development and testing of closed-loop insulin delivery systems in type 1 diabetes mellitus (T1DM).