Lack of association between polymorphisms in STK39 a putative thiazide response gene and blood pressure response to hydrochlorothiazide

摘要

STK39 was previously implicated as a hypertension susceptibility gene and is thought to be involved in control of Na+-Cl− cotransporter (NCC) activity. STK39 has been implicated as a putative thiazide diuretic response gene, as NCC activity is inhibited by thiazides. Thus, we aimed to determine whether STK39 is a thiazide response gene. 195 “good” and 194 “poor” responders to hydrochlorothiazide (HCTZ) were genotyped for approximately 100 single nucleotide polymorphisms (SNPs) within 5000 bases of STK39. SNPs meeting criteria for advancement to replication analysis (P<0.01), along with those previously associated with hypertension, were then analyzed in a second population of 201 HCTZ-treated hypertensives. Two SNPs met these criteria and were analyzed for replication. However, neither these, nor previously implicated SNPs significantly associated with blood pressure response to HCTZ. These data suggest common variants in STK39 likely do not have a clinically relevant role in blood pressure response to HCTZ in hypertensives.