Mathematical Models of the Metabolic System in Health and in Diabetes: Dynamic Modeling of Exercise Effects on Plasma Glucose and Insulin Levels

摘要

BackgroundRegulation of plasma glucose concentration for type 1 diabetic patients is challenging, and exercise is an added complication. From a metabolic prospective, the significant exercise-induced effects are increased glucose uptake rate by the working tissues, increased hepatic glucose release to maintain overall glucose homeostasis, and decreased plasma insulin concentration. During prolonged exercise, glucose levels drop significantly because of the decrease in hepatic glucose production. With the long-term goal of developing a closed-loop insulin delivery system operating under various physiological conditions, it is necessary to develop a model that is capable of predicting blood glucose concentration at rest and during physical activity.