Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel adriamycin-inducible diffuse large B-cell lymphoma (DLBL) growth suppressor

摘要

Diffuse large B-cell lymphoma (DLCL) accounts for 30–40% of adult non-Hodgkin’s Lymphoma (NHL). Current anti-NHL therapies often target cellular growth suppression pathways and include R-CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone plus monoclonal anti-CD20 antibody rituximab). However, since many patients relapse, resistant cells to these therapies remain a significant problem and necessitate development of new intervention strategies. Cell cycle and apoptosis regulatory protein (CARP)-1 functions in a biphasic manner to regulate growth factor as well as chemotherapy (adriamycin, etoposide, or iressa)-dependent signaling.PurposeTo determine whether CARP-1 is a novel suppressor of lymphoma growth.