Pancreatic beta cell mass PET imaging and quantification with 11CDTBZ and 18FFP-(+)-DTBZ in rodent models of diabetes

摘要

PurposeThe aim of this study is to compare the utility of two PET imaging ligands ((+)-[¹¹C]dihydrotetrabenazine ([¹¹C]DTBZ) and the fluoropropyl analogue ([¹⁸F]FP-(+)-DTBZ)) that target islet β-cell vesicular monoamine transporter type II (VMAT2) to measure pancreatic β-cell mass (BCM).