Genetic correlation of blood pressure responses to dietary sodium and potassium intervention and cold pressor test in chinese population

摘要

We examined the genetic association between blood pressure (BP) responses to dietary sodium and potassium intervention and to cold pressor test (CPT) in a large family-based dietary feeding study. The dietary intervention and CPT were conducted among 1906 participants in rural China. The dietary intervention included three 7-day periods of low-sodium feeding (51.3 mmol per day), high-sodium feeding (307.8mmol per day) and high-sodium feeding plus potassium supplementation (60 mmol per day). BP responses to high-sodium intervention had strong genetic correlations (ρG) with both BP responses to low sodium (ρG= −0.43 to −0.54, P-values = 0.0005 to 0.03) and to potassium supplementation (ρG= −0.41 to −0.49, P-values = 0.001 to 0.005) interventions. Most environmental correlations between BP responses to various dietary interventions were significant. The ρG between BP responses to CPT and to high-sodium intervention and potassium supplementation were statistically significant. For example, the ρG between maximum BP responses to CPT and BP responses to high-sodium intervention was 0.37 (P = 0.006) for systolic BP (SBP) and 0.41 (P = 0.002) for diastolic BP (DBP). The ρG between maximum BP responses to CPT and BP responses to potassium intervention was −0.42 (P= 0.001) for SBP and −0.46 (P= 0.001) for SBP. Our study suggests that there are common genetic determinants that influence BP responses to dietary sodium and potassium interventions and to CPT.