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Ribonucleotide reductase subunit M1 expression in resectable muscle-invasive urothelial cancer correlates with survival in younger patients

机译：Ribon核苷酸还原酶亚单位M1在可重演中肌肉侵袭性尿路上皮癌中的表达与年轻患者的存活相关

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ObjectiveTo assess whether high ribonucleotide reductase subunit M1 (RRM1) expression in patients with resected, muscle-invasive (T2–4NxM0) urothelial carcinoma (UC) correlated with longer overall survival (OS). RRM1 is the primary cellular target of gemcitabine and previous studies in resected early-stage lung cancer have shown a survival benefit for patients with high expression.

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期刊名称 other
作者
Lauren C. Harshman; Gerold Bepler; Zhong Zheng; John P. Higgins; Genevera I. Allen; Sandy Srinivas;
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年(卷),期 -1(106),11
年度 -1
页码 1805–1811
总页数 17
原文格式 PDF
正文语种
中图分类
关键词
urothelial carcinoma transitional cell carcinoma of the bladder ribonucleotide reductase RRM1 age prognostic marker survival;

机译：尿路上皮癌;膀胱移行细胞癌;核糖核苷酸还原酶;RRM1;年龄;预后标志物;生存率;

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专利

1. Ribonucleotide reductase subunit M1 expression in resectable, muscle-invasive urothelial cancer correlates with survival in younger patients [J] . Lauren C. Harshman, Gerold Bepler, Zhong Zheng, BJU International . 2010 ,第11期

机译：可切除的，肌肉浸润性尿路上皮癌中的核糖核苷酸还原酶亚基M1表达与年轻患者的生存相关
2. Ribonucleotide reductase subunit M1 expression in resectable, muscle-invasive urothelial cancer correlates with survival in younger patients. [J] . Harshman LC, Bepler G, Zheng Z, BJU international . 2010 ,第11期

机译：可切除的，肌肉浸润性尿路上皮癌中的核糖核苷酸还原酶亚基M1表达与年轻患者的生存相关。
3. The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 (RRM1) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC). [J] . Lee JJ, Maeng CH, Baek SK, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2010 ,第2期

机译：核糖核苷酸还原酶调节亚基M1（RRM1）蛋白质的免疫组织化学过表达是晚期非小细胞肺癌（NSCLC）中基于吉西他滨的化疗生存期较短的预测指标。
4. Network signatures based on gene pair expression ratios improve classification and the analysis of muscle-invasive urothelial cancer [C] . de Matos Simoes Ricardo, Mitsiades Constantine, Williamson Kate E, IEEE International Conference on Bioinformatics and Biomedicine . 2015

机译：基于基因对表达比的网络签名改善了肌肉浸润性尿路上皮癌的分类和分析
5. Characterization of an alternate ribonucleotide reductase small subunit, NrdF1, from Mycobacterium tuberculosis. [D] . Davis, Jamaine Saydu C. 2007

机译：结核分枝杆菌中另一个核糖核苷酸还原酶小亚基NrdF1的特征。
6. Human equilibrative nucleoside transporter-1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression; do they have survival impact to pancreatic cancer? [O] . Dae Wook Hwang, Eun Shin, Jai Young Cho, 2020

机译：人平衡核苷转运蛋白1（hENT1）和核糖核苷酸还原酶调节亚基M1（RRM1）的表达;它们对胰腺癌有生存影响吗？
7. Human equilibrative nucleoside transporter-1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression; do they have survival impact to pancreatic cancer? [O] . Dae Wook Hwang, Eun Shin, Jai Young Cho, 2020

机译：人体平衡核苷转运蛋白-1（HENT1）和核糖核苷酸还原酶调节亚基M1（RRM1）表达;它们是否对胰腺癌生存影响？

Ribonucleotide reductase subunit M1 expression in resectable muscle-invasive urothelial cancer correlates with survival in younger patients

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