Human Umbilical Cord Blood Plasma Can Replace Fetal Bovine Serum (FBS) for in vitro Expansion of Functional Human Endothelial Colony Forming Cells (ECFCs)

摘要

Background aimsA hierarchy of endothelial colony forming cell (ECFC) with different levels of proliferative potential has been identified in human circulating blood and blood vessels. ECFC has recently become an attractive target for new vascular regenerative therapies; however, in vitro expansion of ECFC typically depends on the presence of fetal bovine serum or fetal calf serum (FBS or FCS) in the culture medium; which is not appropriate for its therapeutic application.