Genome-wide Analysis of Loss of Heterozygosity and Copy Number Amplification in Uterine Leiomyomas using the 100K Single Nucleotide Polymorphism Array

摘要

PURPOSEUterine leiomyomas (fibroids) are benign smooth muscle tumors commonly found among reproductive-aged women. Though benign, these tumors are the leading indication for hysterectomies in the United States and cause significant morbidity. Despite the importance of this tumor in women’s health, relatively little is known about the molecular etiology.