Stereoselective Pharmacokinetics of Stable Isotope (+/−)-13C-Pantoprazole: Implications for a Rapid Screening Phenotype Test of CYP2C19 Activity

摘要

AimsWe have previously shown that the (±)-[¹³C]-pantoprazole breath test is a promising noninvasive probe of CYP2C19 activity. As part of that trial, plasma, breath test indices and CYP2C19 (*2, *3 and *17) genotype were collected. Here, we examined whether [¹³C]-pantoprazole exhibits enantioselective pharmacokinetics and whether this enantioselectivity is correlated with indices of breath test.