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Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions and Oxidized LDL Treated Human Monocyte-Derived Macrophages

机译：在先进的动脉粥样硬化病变中增加Wnt5a mRNA表达并氧化LDL处理的人单核细胞衍生的巨噬细胞

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摘要

ObjectiveWnt5a is a secreted glycoprotein highly present in atherosclerotic lesions. Uptake of oxidized-low density lipoprotein (ox-LDL) by monocytes/macrophages plays a critical role in atherosclerosis. The objective of this study was to determine if Wnt5a mRNA expression correlates with the severity of atherosclerotic lesions, and if, ox-LDL can induce Wnt5a mRNA in macrophages.

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期刊名称 other
作者
Pooja M. Bhatt; Christopher J. Lewis; Denise L. House; Chad M. Keller; Leonard D. Kohn; Mitchell J. Silver; Kelly D. McCall; Douglas J. Goetz; Ramiro Malgor;
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年(卷),期 -1(5),-1
年度 -1
页码 1–7
总页数 14
原文格式 PDF
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关键词
Cardiovascular disease atherosclerosis inflammation low density lipoprotein Wnt5a;

机译：心血管疾病;动脉粥样硬化;炎症;低密度脂蛋白;Wnt5a;

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专利

1. Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions,and Oxidized LDL Treated Human Monocyte-Derived Macrophages [J] . Pooja M. Bhatt, ChristopherJ. Lewis, Denise L. House, The Open Circulation & Vascular Journal . 2012,第1期

机译：Wnt5a mRNA在晚期动脉粥样硬化病变和氧化的低密度脂蛋白治疗人单核细胞衍生巨噬细胞中的表达增加。
2. Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo. [J] . Shaw PX, Horkko S, Tsimikas S, Arteriosclerosis, thrombosis, and vascular biology . 2001,第8期

机译：人类衍生的抗氧化LDL自身抗体可阻止巨噬细胞摄取氧化LDL，并在体内定位于动脉粥样硬化病变。
3. Induced expression of adipophilin mRNA in human macrophages stimulated with oxidized low‐density lipoprotein and in atherosclerotic lesions [J] . Burnand Kevin G., Li Xiang, Lysko Paul G., FEBS Letters . 1999,第1a2期

机译：氧化性低密度脂蛋白刺激的人巨噬细胞和动脉粥样硬化病变中adipophilin mRNA的诱导表达
4. Plaque instability in human coronary atherosclerotic lesions: roles of oxidized LDL and neutrophils [C] . Makiko Ueda, Shoichi Ehara, Yoshiki Kobayashi International Symposium on Atherosclerosis . 2004

机译：人类冠状动脉粥样硬化病变中的斑块不稳定：氧化LDL和中性粒细胞的作用
5. Alteration of microRNA expression profiles of primary human monocyte-derived macrophage exosomes upon activation [D] . Emanuel, Katy M. 2015

机译：激活后原代人单核细胞巨噬细胞外泌体的microRNA表达谱的变化
6. Oleacein and Foam Cell Formation in Human Monocyte-Derived Macrophages: A Potential Strategy against Early and Advanced Atherosclerotic Lesions [O] . Agnieszka Filipek, Tomasz P. Mikołajczyk, Tomasz J. Guzik, 2020

机译：人单核细胞衍生的巨噬细胞中的糖素和泡沫细胞形成：针对早期和晚期动脉粥样硬化病变的潜在策略
7. Human-Derived Anti–Oxidized LDL Autoantibody Blocks Uptake of Oxidized LDL by Macrophages and Localizes to Atherosclerotic Lesions In Vivo [O] . Pojen P. Chen, Joseph L. Witztum, Peter X. Shaw, 2015

机译：人源抗氧化LDL自身抗体阻断巨噬细胞对氧化LDL的摄取并定位于体内动脉粥样硬化病变

Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions and Oxidized LDL Treated Human Monocyte-Derived Macrophages

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