Unraveling the Numerous Biosynthetic Products of the Marine Sediment-Derived Fungus Aspergillus insulicola

摘要

A new tripeptide, pre-sclerotiotide F (>3), was isolated from a marine sediment-derived fungus, Aspergillus insulicola, along with five known compounds, one of which was new at the time of isolation, scerotiotide F (>4). The absolute configuration elucidation of the new compound was determined using a combination of NMR, HR-ESI-MS, and optical rotation analyses. Cytotoxicities were measured in vitro against selected cancer cells. The effects of pre-sclerotiotide F (>3) and sclerotiotide F (>4) on LPS-induced NF-κB and iNOS expression were also measured.