Bioavailability of S-Adenosyl Methionine and Impact on Response in a Randomized Controlled Trial in Major Depressive Disorder

摘要

ObjectiveTo characterize the impact of S-adenosylmethionine (SAMe) on homocysteine, and potential risk of adverse cardiovascular effects, by examining plasma levels of SAMe, S-adenosylhomocysteine (SAH), total homocysteine (tHCY), methionine (MET), and 5-methyltetrahydrofolate (5-MHTF) in 35 of 73 patients from a 6-week double-blind randomized trial of SAMe augmentation in serotonin-reuptake inhibitor partial responders with DSM-IV major depressive disorder (MDD), published in 2010.