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Upregulation of Mucin4 in ER-positive/HER2-Overexpressing Breast Cancer Xenografts with Acquired Resistance to Endocrine and HER2-Targeted Therapies

机译：在ER-阳性/ HER2过度抑制乳腺癌异种移植物中的母蛋白4在内分泌和HER2针对疗法中的抗癌异种移植物中的上调

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BackgroundWe studied resistance to endocrine and HER2-targeted therapies using a xenograft model of estrogen receptor positive (ER)/HER2-overexpressing breast cancer. Here, we report a novel phenotype of drug resistance in this model.

机译：背景技术使用雌激素受体阳性（ER）/ Her2-过度抑制乳腺癌的异种移植模型研究了对内分泌和HER2靶向疗法的抗性。在这里，我们在该模型中报告了一种新的耐药性表型。

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期刊名称 other
作者
Albert C. Chen; Ilenia Migliaccio; Mothaffar Rimawi; Sara Lopez-Tarruella; Chad J. Creighton; Suleiman Massarweh; Catherine Huang; Yen-Chao Wang; Surinder K. Batra; M. Carolina Gutierrez; C. Kent Osborne; Rachel Schiff;
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年(卷),期 -1(134),2
年度 -1
页码 583–593
总页数 17
原文格式 PDF
正文语种
中图分类
关键词
Breast cancer mucin4 mucinated phenotype mucins endocrine therapy HER2 therapy drug resistance;

机译：乳腺癌;粘蛋白4;表型;粘蛋白;内分泌治疗;HER2治疗;耐药;

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专利

1. Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies. [J] . Albert C Chen, Ilenia Migliaccio, Mothaffar Rimawi, Breast cancer research and treatment. . 2012,第2期

机译：ER阳性/ HER2过表达的乳腺癌异种移植物中mucin4的上调，对内分泌和靶向HER2的疗法具有抗性。
2. Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies [J] . Albert C. Chen, Ilenia Migliaccio, Mothaffar Rimawi, Breast Cancer Research and Treatment . 2012,第2期

机译：具有内分泌和HER2靶向治疗耐药性的ER阳性/ HER2过表达的乳腺癌异种移植物中mucin4的上调
3. HEALTH-RELATED QUALITY OF LIFE IN 2ND-LINE ENDOCRINE THERAPY FOR PATIENTS WITH ACQUIRED ENDOCRINE-RESISTANT POSTMENOPAUSAL ER-POSITIVE, HER2-NEGATIVE METASTATIC BREAST CANCER: THE HORSE-BC STUDY [J] . Kikawa Yuichiro, Sakamaki Kentaro, Fujisawa Tomomi, The Breast : . 2019,第Suppla2期

机译：2ND-Line内分泌治疗的健康状生活质量为患有内分泌耐药后患者ER-阳性，HER2阴性转移性乳腺癌：马BC研究
4. A Single Tube Screening of Endocrine Therapy Resistance ESR1 Mutations in ER-Positive Breast Cancer [C] . Akihiro Tsuyada, Shunsuke Nakano, Toshimitsu Ichijo, International Molecular Medicine Tri-Conference. . 2016

机译：ER阳性乳腺癌内分泌治疗抗ESR1突变的单管筛选
5. Novel Approaches to Endocrine Therapy in Endocrine-Independent Breast Cancer [D] . Patel, Hitisha K. 2016

机译：内分泌非依赖性乳腺癌的内分泌治疗新方法
6. HSP90 Inhibitor 17-DMAG Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive HER2-Overexpressing Breast Cancer Cell Line [O] . Hye Jin Lee, Seungho Shin, Jinho Kang, 2020

机译：HSP90抑制剂17-DMAg单独和与Lapatinib的组合衰减在ER阳性的HER阳性的乳腺癌细胞系中获得的Lapatinib抗性
7. Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies [O] . Albert C. Chen, Ilenia Migliaccio, Mothaffar Rimawi, 2012

机译：在ER-阳性/ HER2过度抑制乳腺癌异种移植物中的母蛋白4在内分泌和HER2针对疗法中的抗癌异种移植物中的上调
8. Mixed Lineage Kinases as Novel Targets for the Treatment of Endocrine-Resistant, ER-Positive Breast Cancer. [R] . Conrad, S. E. 2016

机译：混合谱系激酶作为治疗内分泌抗性，ER阳性乳腺癌的新靶点。

Upregulation of Mucin4 in ER-positive/HER2-Overexpressing Breast Cancer Xenografts with Acquired Resistance to Endocrine and HER2-Targeted Therapies

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