Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter

摘要

PurposeInhibitors of protein prenylation, including prenyltransferase inhibitors and aminobisphosphonates such as zoledronic acid, are being investigated intensively as therapeutics in cancer and other diseases. Determining whether prenylation inhibitors directly or indirectly target tumor and/or host cells is key to understanding therapeutic mechanisms.