Effect of treadmill exercise on PI3K/AKT/mTOR autophagy and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice

机译：跑步机运动对NSE / htau23转基因小鼠大脑皮层PI3K / AKT / mTOR自噬和Tau过度磷酸化的影响

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PurposeNeurofibrillary tangles, one of pathological features of Alzheimer’s disease, are produced by the hyperphosphorylation and aggregation of tau protein. This study aimed to investigate the effects of treadmill exercise on PI3K/AKT/mTOR signal transmission, autophagy, and cognitive ability that are involved in the hyperphosphorylation and aggregation of tau protein.

机译：目的神经纤维缠结是阿尔茨海默氏病的病理特征之一，是由tau蛋白的过度磷酸化和聚集产生的。这项研究旨在调查跑步机锻炼对PI3K / AKT / mTOR信号传递，自噬和tau蛋白超磷酸化和聚集所涉及的认知能力的影响。

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期刊名称 Journal of Exercise Nutrition Biochemistry
作者
Eun-Bum Kang; Joon-Yong Cho;
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作者单位

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年(卷),期 2015(19),3
年度 2015
页码 199–209
总页数 11
原文格式 PDF
正文语种
中图分类生物学;
关键词
Alzheimer’s disease treadmaill exercise tau hyperphosphorylayion PI3K/AKT/smTOR signaling pathway autophagy cognitive function;

机译：阿尔茨海默氏病;胎盘锻炼;tau蛋白过度磷酸化;PI3K / AKT / smTOR信号通路;自噬;认知功能;

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专利

1. MiR-539-5p Decreases amyloid beta-protein production, hyperphosphorylation of Tau and Memory Impairment by Regulating PI3K/Akt/GSK-3 beta Pathways in APP/PS1 Double Transgenic Mice [J] . Ecological restoration . 2020,第2期

机译：MiR-539-5P通过调节APP / PS1双转基因小鼠的PI3K / AKT / GSK-3β途径降低淀粉样蛋白β-蛋白质产生，TAU和记忆障碍的高磷酸化
2. MiR-539-5p Decreases amyloid beta-protein production, hyperphosphorylation of Tau and Memory Impairment by Regulating PI3K/Akt/GSK-3 beta Pathways in APP/PS1 Double Transgenic Mice [J] . Jiang Yushu, Zhang Yuan, Su Li Neurotoxicity research . 2020,第2期

机译：MiR-539-5P通过调节APP / PS1双转基因小鼠的PI3K / AKT / GSK-3β途径降低淀粉样蛋白β-蛋白质产生，TAU和记忆障碍的高磷酸化
3. Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K/Akt/mTOR signaling pathway: involvement of blood-brain barrier's tight junction proteins [J] . Manthari Ram Kumar, Tikka Chiranjeevi, Ommati Mohammad Mehdi, Archives of Toxicology . 2018,第11期

机译：砷通过抑制PI3K / AKT / MTOR信号通路诱导发育小鼠脑皮质和海马的自噬：血脑屏障的紧密结蛋白的累积
4. Neuroprotective effects of treadmill exercise on BDNF and PI3-K/Akt signaling pathway in the cortex of transgenic mice model of Alzheimer’s disease [O] . Jung Hoon Koo, In Su Kwon, Eun Bum Kang, 2013

机译：跑步机运动对阿尔茨海默病转基因小鼠皮层中BDNF和PI3-K / Akt信号通路的神经保护作用
5. Neuroprotective effects of treadmill exercise on BDNF and PI3-K/Akt signaling pathway in the cortex of transgenic mice model of Alzheimer’s disease [O] . Jung Hoon Koo, In Su Kwon, Eun Bum Kang, 2013

机译：跑步机锻炼对BDNF和PI3-K / AKT信号通路在阿尔茨海默病转基因小鼠模型中的BDNF和PI3-K / AKT信号通路的神经保护作用

Effect of treadmill exercise on PI3K/AKT/mTOR autophagy and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice

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