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Antitumor Activity of Emodin against Pancreatic Cancer Depends on Its Dual Role: Promotion of Apoptosis and Suppression of Angiogenesis

机译：血管生成的细胞凋亡的促进和抑制大黄素对其双重作用的抗肿瘤活性抗胰腺癌Depends中

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BackgroundEmodin has been showed to induce apoptosis of pancreatic cancer cells and inhibit tumor growth in our previous studies. This study was designed to investigate whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.

机译：背景在我们以前的研究中，大黄素已被证明可诱导胰腺癌细胞凋亡并抑制肿瘤生长。本研究旨在探讨大黄素是否可以抑制胰腺癌组织的血管生成及其机制。

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期刊名称 other
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Sheng-Zhang Lin; Wei-Tian Wei; Hui Chen; Kang-Jie Chen; Hong-Fei Tong; Zhao-Hong Wang; Zhong-Lin Ni; Hai-Bin Liu; Hong-Chun Guo; Dian-Lei Liu;
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年(卷),期 -1(7),8
年度 -1
页码 e42146
总页数 15
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专利

1. The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer. [J] . Miyake K, Shimada M, Nishioka M, Cancer letters . 2008,第2期

机译：新型缺氧细胞放射增敏剂TX-1877通过抑制血管生成具有抗肿瘤活性，并抑制胰腺癌异种移植模型的肝转移。
2. Emodin potentiates the antitumor effects of gemcitabine in PANC-1 pancreatic cancer xenograft model in vivo via inhibition of inhibitors of apoptosis [J] . Hong-Chun Guo, He-Qi Bu, Jiang Luo, International journal of oncology . 2012,第6期

机译：大黄素通过抑制凋亡抑制剂来增强吉西他滨在PANC-1胰腺癌异种移植模型中的抗肿瘤作用
3. Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation [J] . Wei-Τian Wei, Hui Chen, Zhong-Lin Ni, International journal of oncology . 2011,第6期

机译：大黄素蒽醌衍生物大黄素大黄素通过抑制Akt活化来抗小鼠胰腺癌的抗肿瘤和促凋亡作用。
4. Research on Anti-Metastasis Effect of Emodin on Pancreatic Cancer [C] . Haishuai Yu International symposium on IT in medicine and education . 2014

机译：大黄素对胰腺癌抗转移作用的研究
5. Erythropoietin biology in cancer: A role in apoptosis and angiogenesis. [D] . Hardee, Matthew Emery. 2007

机译：促红细胞生成素生物学在癌症中：在凋亡和血管生成中的作用。
6. Traditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation invasiveness and apoptosis [O] . Jun Wu, Jing Wang, Qiang Su, 2018

机译：中药黄芪多糖增强血管生成抑制剂阿帕替尼对胰腺癌细胞增殖侵袭和凋亡的抗肿瘤作用
7. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis. [O] . Sheng-Zhang Lin, Wei-Tian Wei, Hui Chen, 2012

机译：大黄素对胰腺癌的抗肿瘤活性取决于其双重作用：促进细胞凋亡和抑制血管生成。
8. Suppression of NFkB by Tetrathiomolybdate Inhibits Tumor Angiogenesis and Enhances Apoptosis in Human Breast Cancers [R] . Pan, Q. 2005

机译：四硫代钼酸盐抑制NFkB抑制肿瘤血管生成并增强人乳腺癌细胞凋亡

Antitumor Activity of Emodin against Pancreatic Cancer Depends on Its Dual Role: Promotion of Apoptosis and Suppression of Angiogenesis

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