MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance

机译：MNAT1在结直肠癌中过表达并介导p53泛素降解以促进结直肠癌

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BackgroundMNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, high expresses in various cancers and is involved in cancer pathogenesis. However, mechanisms underlying its regulation in carcinogenesis are unclear.

机译：背景MNAT1（管理三叉戟1，MAT1）是一种细胞周期蛋白依赖性激酶激活激酶（CAK）复合物，在多种癌症中高表达，并参与癌症的发病机理。但是，尚不清楚其调控致癌作用的机制。

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期刊名称 Journal of Experimental Clinical Cancer Research : CR
作者
Shan Zhou; Jinping Lu; Yuejin Li; Chan Chen; Yongqiang Cai; Gongjun Tan; Zhengke Peng; Zhenlin Zhang; Zigang Dong; Tiebang Kang; Faqing Tang;
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作者单位

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年(卷),期 2018(37),-1
年度 2018
页码 284
总页数 17
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
MNAT1 Colorectal cancer p53 Ubiquitin Tumorigenesis;

机译：MNAT1;结肠直肠癌;p53;泛素;肿瘤发生;

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专利

1. MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance [J] . Shan Zhou, Jinping Lu, Yuejin Li, Journal of experimental & clinical cancer research : . 2018,第1期

机译：MNAT1在结直肠癌中过表达，并介导p53泛素降解以促进结直肠癌
2. Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth [J] . Yu Cheng, Yujiao Hu, Huanxi Wang, Journal of cellular and molecular medicine. . 2021,第16期

机译：在非小细胞肺癌中过表达无戒指蛋白质19a，并介导P53泛素降解以促进癌症生长
3. MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance [J] . Jinping Lu, Yuejin Li, Yuanzhong Wu, Theranostics . 2018,第19期

机译：MICAL2通过氧化p53蛋氨酸40和160介导p53泛素降解并促进结直肠癌恶性肿瘤。
4. Reprimo 824 G>C and p53R2 4696 G>C Single Nucleotide Polymorphisms in Healthy, Diverticular Disease and Colorectal Cancer Populations [C] . W. Beasle European Society for Surgical Research . 2005

机译：谴责824g> c和p53r2 4696 g> c健康，憩室疾病和结直肠癌种群中的单核苷酸多态性
5. Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies in breast, lung, colorectal, ovarian, and endometrial cancer [D] . Dahabreh, Issa J. 2011

机译：rs1042522 TP53（Arg72Pro）多态性的遗传关联研究中的基因型错误分类：对乳腺癌，肺癌，结直肠癌，卵巢癌和子宫内膜癌研究的系统评价
6. MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance [O] . Jinping Lu, Yuejin Li, Yuanzhong Wu, 2018

机译：MICAL2通过氧化p53蛋氨酸40和160介导p53泛素降解并促进结直肠癌恶性肿瘤。
7. Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF [O] . Rongsheng Zhang, Fan Qi, Shengli Shao, 2019

机译：人结直肠癌衍生的癌相关成纤维细胞促进CD44介导的结直肠癌细胞的粘附通过分泌HGF的内皮细胞

MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance

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