Effectiveness of Radiation for Prevention of Mastectomy in Older Breast Cancer Patients Treated with Conservative Surgery

摘要

PurposeA recent clinical trial concluded that radiation therapy (RT) does not lower risk of mastectomy and thus may be omitted in older women with stage I, estrogen receptor (ER)-positive breast cancer treated with conservative surgery (CS). However, it is not known whether this finding applies to patients outside a clinical trial. Accordingly, we used the SEER-Medicare observational cohort to determine the effect of RT on risk of mastectomy among older women with stage I, ER+ breast cancer.