Enterocyte Expression of Epidermal Growth Factor Receptor is Not Required for Intestinal Adaptation in Response to Massive Small Bowel Resection

摘要

PurposeIntestinal adaptation following massive small bowel resection (SBR) permits improved absorption of enteral nutrition despite significant loss of bowel length. Epidermal growth factor (EGF) and its receptor (EGFR) have previously been established to play major roles in the pathogenesis of adaptation. This study tested the hypothesis that EGFR signaling within the epithelial cell compartment (enterocytes) is required for intestinal adaptation.