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Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

机译：基因组研究识别与轻度至中度COPD中的肺功能下降的两个基因座

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RationaleAccelerated lung function decline is a key COPD phenotype; however its genetic control remains largely unknown.

机译：理由加速的肺功能下降是COPD的关键表型。然而，其遗传控制仍然未知。

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期刊名称 other
作者
Nadia N Hansel; Ingo Ruczinski; Nicholas Rafaels; Don D Sin; Denise Daley; Alla Malinina; Lili Huang; Andrew Sandford; Tanda Murray; Yoonhee Kim; Candelaria Vergara; Susan R Heckbert; Bruce M Psaty; Guo Li; W. Mark Elliott; Farzian Aminuddin; Josée Dupuis; George O’Connor; Kimberly Doheny; Alan F Scott; H Marike Boezen; Dirkje S Postma; Joanna Smolonska; Pieter Zanen; Firdaus A Mohamed Hoesein; Harry J de Koning; Ron Crystal; Toshiko Tanaka; Luigi Ferrucci; Edwin Silverman; Emily Wan; Jorgen Vestbo; David A Lomas; John Connett; Robert A Wise; Enid R Neptune; Rasika A Mathias; Peter D Paré; Terri H Beaty; Kathleen C Barnes;
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年(卷),期 -1(132),1
年度 -1
页码 79–90
总页数 21
原文格式 PDF
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关键词
COPD lung function decline GWAS genome wide association genes polymorphisms;

机译：COPD;肺功能下降;GWAS;全基因组关联;基因;多态性;

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专利

1. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD [J] . HanselN.N., RuczinskiI., RafaelsN., Human Genetics . 2013,第1期

机译：全基因组研究确定了轻度至中度COPD肺功能下降相关的两个基因座
2. Predictors of lung function and its decline in mild to moderate COPD in association with gender: results from the Euroscop study. [J] . Watson L, Vonk JM, Lofdahl CG, Respiratory medicine . 2006,第4期

机译：与性别相关的肺功能及其轻度至中度COPD下降的预测指标：Euroscop研究的结果。
3. CT screening in COPD: Impact on lung cancer mortality: De Torres JP, Casanova C, Marin JM et al. Exploring the impact of screening with low-dose CT on lung cancer mortality in mild to moderate COPD patients: A pilot study. Respir Med 2013; 107: 702-707 [J] . YoungR.P., HopkinsR.J. Respiratory medicine . 2014,第5期

机译：COPD中的CT筛查：对肺癌死亡率的影响：De Torres JP，Casanova C，Marin JM等。探索低剂量CT筛查对轻度至中度COPD患者肺癌死亡率的影响：一项先导研究。 2013年Respir Med; 107：702-707
4. Genome-wide interaction study identifies Cadherin 13 as effect modifier of cumulative PM10 exposure on lung function decline [C] . Medea Imboden, Christian Schindler, Ashish Kumar, Annual conference of the International Society of Exposure Science . 2014

机译：全基因组相互作用研究确定钙黏着蛋白13是累积PM10暴露对肺功能下降的影响调节剂
5. mCOPD: Mobile Phone Based Lung Function Diagnosis and Exercise System for COPD. [D] . Liu, Xiao. 2013

机译：mCOPD：用于COPD的基于手机的肺功能诊断和锻炼系统。
6. Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis [O] . Wenjia Chen, Mohsen Sadatsafavi, J. Mark FitzGerald, 2021

机译：性别改变体重指数对轻度至中度COPD患者肺功能下降的影响：汇集分析
7. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD [O] . Hansel, Nadia N, Ruczinski, Ingo, Rafaels, Nicholas, 2013

机译：全基因组研究确定了轻度至中度COPD肺功能下降相关的两个基因座

Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

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