Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non-small cell lung cancer; Results from CALGB 159902

摘要

IntroductionPrevious studies suggest cytologic analysis of cells obtained by lavage of the pleural surfaces at the time of resection of non-small cell lung cancer (NSCLC) can identify patients at risk for recurrence. Because telomerase gene expression has been associated with worse outcome in NSCLC, we hypothesized that identification of cells obtained from pleural lavage that express telomerase would identify patients at risk for recurrent disease.