Serum Glutamate Levels Correlate with Gleason Score and Glutamate Blockade Decreases Proliferation Migration and Invasion and Induces Apoptosis in Prostate Cancer Cells

摘要

PurposeDuring glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with primary prostate cancer (PCa) or metastatic castrate-resistant PCa (mCRPCa) to establish clinical relevance. The effect of glutamate-deprivation or blockade by metabotropic glutamate receptor 1 (GRM1)-antagonists was investigated on PCa cells’ growth, migration, and invasion to establish biological relevance.