Copper-Promoted Sulfenylation of sp2 C-H Bonds

摘要

An auxiliary-assisted, copper catalyzed or promoted sulfenylation of benzoic acid derivative β-C–H bonds and benzylamine derivative γ-C–H bonds has been developed. The method employs disulfide reagents, copper (II) acetate, and DMSO solvent at 90–130 °C. Application of this methodology to the direct trifluoromethylsulfenylation of C–H bonds was demonstrated.