DNA methylation as an adjunct to histopathology to detect prevalent inconspicuous dysplasia and early-stage neoplasia in Barrett’s esophagus

摘要

PurposeEndoscopic surveillance of Barrett’s esophagus (BE) is problematic because dysplasia/early-stage neoplasia are frequently invisible and likely to be missed due to sampling bias. Molecular abnormalities may be more diffuse than dysplasia. The aim was therefore to test whether DNA methylation; especially on imprinted and X-chromosome genes; is able to detect dysplasia/early-stage neoplasia.