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Nuclease Digestion and Mass Spectrometric Characterization of Oligodeoxyribonucleotides Containing 12-GpG 12-ApG and 13-GpXpG Cisplatin Intrastrand Cross-links

机译：含有12-GPG12-APG和13-GPXPG顺铂卵巢交联的寡聚寡核糖核苷酸的核酸酶消化和质谱表征

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摘要

BackgroundThe primary mode of action for cis-diamminedichloroplatinum (II), referred to as cisplatin, towards the treatment of solid malignancies is through formation of cross-links with DNA at purine sites, especially guanines.

机译：背景技术顺二氨二氯铂（II）（称为顺铂）对固体恶性肿瘤的治疗的主要作用方式是通过在嘌呤位点，特别是鸟嘌呤上与DNA形成交联。

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期刊名称 other
作者
Renee T. Williams; Jenifer Nalbandian; Audrey Tu; Yinsheng Wang;
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年(卷),期 -1(420),-1
年度 -1
页码 160–170
总页数 20
原文格式 PDF
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关键词
mass spectrometry HPLC stable isotope labeling DNA digestion and cisplatin;

机译：质谱;HPLC;稳定同位素标记;DNA消化和顺铂;

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专利

1. Nuclease digestion and mass spectrometric characterization of oligodeoxyribonucleotides containing 1,2-GpG, 1,2-ApG, and 1,3-GpXpG cisplatin intrastrand cross-links [J] . WilliamsR.T., NalbandianJ.N., TuA., Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2013,第Null期

机译：含有1,2-GpG，1,2-ApG和1,3-GpXpG顺铂链内交联的寡脱氧核糖核苷酸的核酸酶消化和质谱表征
2. Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin l,2-d(GG) Intrastrand Cross-Link:Comparison with the Same DNA Duplex Containing an Oxaliplatin l,2-d(GG) Intrastrand Cross-Link [J] . Yibing Wu, Debadeep Bhattacharyya, Candice L.King Biochemistry . 2007,第22期

机译：具有和不具有顺铂l，2-d（GG）内链交联的DNA Dodecamer双链体的溶液结构：具有含奥沙利铂l，2-d（GG）内链交联的相同DNA双链体的比较
3. 1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin [J] . Moriarity B, Novakova O, Farrell N, Archives of Biochemistry and Biophysics . 2007,第2期

机译：抗肿瘤双核双功能铂化合物与亚精胺接头的1,2-GG链内交联比常规顺铂的交联更有效地抑制DNA聚合
4. Structural determination of drug-substance related variants using in-gel digestion coupled with Mass Spectrometric Characterization [C] . Xiaojing Zheng, Nikita Kulkarni, Ning Li American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用凝胶消化的药物 - 物质相关变体的结构测定与质谱结合
5. Molecular dosimetry of 1,2 guanine-guanine intrastrand cross links of cisplatin by ultra performance liquid chromatography tandem mass spectrometry. [D] . Baskerville-Abraham, Irene M. 2009

机译：超高效液相色谱串联质谱法测定顺铂1,2鸟嘌呤-鸟嘌呤链内交联的分子剂量。
6. Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 12-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 12-d(GG) Intrastrand Cross-Link [O] . Yibing Wu, Debadeep Bhattacharyya, Candice L. King, -1

机译：具有和不具有顺铂12-d（GG）内链交联的DNA Dodecamer双链体的溶液结构：与包含奥沙利铂12-d（GG）内链交联的相同DNA双链体的比较
7. Nuclease digestion and mass spectrometric characterization of oligodeoxyribonucleotides containing 1,2-GpG, 1,2-ApG, and 1,3-GpXpG cisplatin intrastrand cross-links [O] . Renee T. Williams, Jenifer N. Nalbandian, Audrey Tu, 2013

机译：含有1,2-GPG，1,2-APG和1,3-GPXPG顺铂卵巢交联的寡聚寡核糖核苷酸的核酸酶消化和质谱表征

Nuclease Digestion and Mass Spectrometric Characterization of Oligodeoxyribonucleotides Containing 12-GpG 12-ApG and 13-GpXpG Cisplatin Intrastrand Cross-links

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