Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA AFAP1-AS1 in Barrett’s Esophagus and Esophageal Adenocarcinoma

摘要

BACKGROUND & AIMSAlterations in methylation of protein-coding genes are associated with Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). Dys-regulation of noncoding RNAs occurs during carcinogen-esis but has never been studied in BE or EAC. We applied high-resolution methylome analysis to identify changes at genomic regions that encode noncoding RNAs in BE and EAC.