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Pharmacokinetics of Two Common Antiretroviral Regimens in Older HIV-Infected Patients: A Pilot Study

机译：老年艾滋病毒感染患者中两种常见抗逆转录病毒治疗方法的药代动力学：试验研究

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摘要

BackgroundThe pharmacokinetics (PK) of antiretrovirals (ARVs) in older HIV-infected patients are poorly described. Here, the steady-state PK of 2 common ARV regimens (tenofovir [TFV]/emtricitabine [FTC]/efavirenz [EFV]; TFV/FTC/atazanavir [ATV]/ritonavir [RTV]) in older non-frail HIV-infected patients are presented.

机译：背景：抗逆转录病毒药物（ARVs）在感染艾滋病毒的老年患者中的药代动力学（PK）描述不多。在这里，在较老的脆弱性较弱的HIV感染者中，两种常见的ARV方案（替诺福韦[TFV] /恩曲他滨[FTC] / efavirenz [EFV]； TFV / FTC / atazanavir [ATV] /利托那韦[RTV]）的稳态PK病人介绍。

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期刊名称 other
作者
Julie B. DUMOND; Jessica L. ADAMS; Heather M.A. PRINCE; Racheal L. KENDRICK; Ruili WANG; Steven H. JENNINGS; Stephanie MALONE; Nicole WHITE; Craig SYKES; Amanda H. CORBETT; Kristine B. PATTERSON; Alan FORREST; Angela D.M. KASHUBA;
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年(卷),期 -1(14),7
年度 -1
页码 401–409
总页数 14
原文格式 PDF
正文语种
中图分类
关键词
Pharmacokinetics Aging Intracellular Pharmacokinetics;

机译：药代动力学;衰老;细胞内药代动力学;

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专利

1. Pharmacokinetics of two common antiretroviral regimens in older HIV-infected patients: A pilot study [J] . DumondJ., AdamsJ., PrinceH., HIV medicine . 2013,第7期

机译：老年HIV感染患者中两种常见抗逆转录病毒疗法的药代动力学：一项初步研究
2. Efficacy and pharmacokinetics of the combination of etravirine plus raltegravir as novel dual antiretroviral maintenance regimen in HIV-infected patients [J] . Casado Jose L., Banon Sara, Rodriguez Miguel A., Antiviral Research . 2015,第期

机译：Etravirine Plus Raltegravir作为艾滋病毒感染患者新型双抗逆转录病毒维持方案的疗效和药代动力学
3. Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Na?ve to Antiretroviral Therapy: A Pilot Randomized Trial [J] . Sergio Serrano-Villar, Talia Sainz, Zhong-Min Ma, PLoS Pathogens . 2016,第1期

机译：联合CCR5 /基于整合酶抑制剂的方案对单纯接受抗逆转录病毒治疗的HIV感染患者的粘膜免疫的影响：一项随机试验
4. The Two First-Line Recommended Antiretroviral Regimens for Naive HIV-Infected Patients: Efavirenz-Based Versus Lopinavir-Ritonavir-Based Haart [C] . R. Manfredi, L. Calza, F. Chiodo International AIDS Conference . 2004

机译：幼稚艾滋病毒感染患者的两种第一线推荐的抗逆转录病毒方案：efavirenz为基于Lopinavir-Ritonavir的HAART
5. Antiretroviral regimen central nervous penetration, viral control, and age of attainment of developmental milestones in early treated HIV-infected infants. [D] . Crowell, Claudia S. 2015

机译：抗逆转录病毒疗法的中枢神经渗透，病毒控制和达到早期里程碑的HIV感染婴儿的发展里程碑年龄。
6. Impact of Efavirenz- Ritonavir-Boosted Lopinavir- and Nevirapine-Based Antiretroviral Regimens on the Pharmacokinetics of Lumefantrine and Safety of Artemether-Lumefantrine in Plasmodium falciparum-Negative HIV-Infected Malawian Adults Stabilized on Antiretroviral Therapy [O] . Clifford G. Banda, Fraction Dzinjalamala, Mavuto Mukaka, 2018

机译：依非韦伦利托那韦增强的洛匹那韦和奈韦拉平为基础的抗逆转录病毒疗法对恶性疟原虫阴性艾滋病毒感染的马拉维成虫中鲁美替林的药代动力学和蒿甲醚-卢美他汀安全性的影响被抗逆转录病毒稳定
7. Pharmacokinetics of two common antiretroviral regimens in older HIV-infected patients: a pilot study [O] . JB Dumond, JL Adams, HMA Prince, 2013

机译：老年艾滋病毒感染患者中两种常见抗逆转录病毒治疗方法的药代动力学：试验研究

Pharmacokinetics of Two Common Antiretroviral Regimens in Older HIV-Infected Patients: A Pilot Study

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