Exploring intra- and inter-reader variability in uni-dimensional bi-dimensional and volumetric measurements of solid tumors on CT scans reconstructed at different slice intervals

摘要

ObjectiveUnderstanding magnitudes of variability when measuring tumor size may be valuable in improving detection of tumor change and thus evaluating tumor response to therapy in clinical trials and care. Our study explored intra- and inter-reader variability of tumor uni-dimensional (1D), bi-dimensional (2D), and volumetric (VOL) measurements using manual and computer-aided methods (CAM) on CT scans reconstructed at different slice intervals.