An improved synthesis of 1′-18Ffluoroethyl-β-D-lactose (18F-FEL) for positron emission tomography imaging of pancreatic cancer

摘要

IntroductionEarlier, we reported syntheses of ethyl-β-D-galactopyranosyl-(1,4′)-2′-deoxy-2′-[¹⁸F]fluoro-β-D-glucopyranoside (Et-[¹⁸F]FDL) and 1′-[¹⁸F]fluoroethyl-β-D-lactose ([¹⁸F]-FEL) for positron emission tomography (PET) of pancreatic carcinoma. Et-[¹⁸F]FDL requires a precursor, which involves 11 steps to synthesize and produces overall low yields. Synthesis of precursors for [¹⁸F]-FEL requires four steps, but those precursors produced low radiochemical yields. Here, we report new precursors and an improved synthesis of [¹⁸F]-FEL.