The Circadian Per1 and Per2 Genes Influence Alcohol Intake Reinforcement and Blood Alcohol Levels

摘要

BackgroundPerturbations in the function of core circadian clock components such as the Period (Per) family of genes are associated with alcohol use disorder, and disruptions in circadian cycles may contribute to alcohol abuse and relapse. This study tested ethanol consumption, reinforcement, and metabolism in mice containing functional mutations in Per1 and/or Per2 genes on an ethanol-preferring background, C57BL/6J mice.