Single Nucleotide Polymorphisms in Nucleotide Excision Repair Genes Cigarette Smoking and the Risk of Head and Neck Cancer

摘要

BackgroundCigarette smoking is associated with increased head and neck cancer (HNC) risk. Tobacco-related carcinogens are known to cause bulky DNA adducts. Nucleotide excision repair (NER) genes encode enzymes that remove adducts and may be independently associated with HNC, as well as modifiers of the association between smoking and HNC.